Metabolism of Dehydroepiandrosterone Sulfate and Estrone-Sulfate by Human Platelets
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چکیده
منابع مشابه
Metabolism of dehydroepiandrosterone sulfate and estrone-sulfate by human platelets.
The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine capacity of human platelets to produce sex steroid hormones. The DHEAS transport was evaluated through the uptake of [(3)H]-DHEAS in the presence or absence of different substrates through the organic anion transporting polypeptide (OATP) family. The activity of sulfatase enzyme was evaluated, and ...
متن کاملEstrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma.
The activity of the two membrane-bound sulfatases, estrone and dehydroepiandrosterone sulfatases, are reported in human breast carcinoma tissues. In 21 tested tumors (12 from post-menopausal women and 9 from nonmenopausal women), the two sulfatases were consistently present. The apparent Km values for estrone and dehydroepiandrosterone sulfatases were, respectively, 6.8 and 14.9 microM. In term...
متن کاملEstrone sulfate: production rate and metabolism in man.
Since estrone sulfate (E(1)S) is present at high concentration in plasma, we have examined the parameters of the plasma estrone, estradiol, E(1)S system. The metabolic clearance rate of E(1)S was 157 liter/day (range 70-292) in men and women. Estimated plasma production rates of E(1)S were (mugrams per day): men, 77; women, early follicular phase, 95; women, early luteal phase, 182. The convers...
متن کاملSerum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.
BACKGROUND Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS Steroids extracted with methanol from serum sample were...
متن کاملThe characterization of estrone sulfate from human plasma.
The literature regarding estrogens in human blood has recently been reviewed (I), and it was concluded that only a preliminary qualitative outline of the subject is discernible. No chemical method has yet succeeded in unequivocally characterizing the trace quantities of estrogens in blood. Preliminary consideration has so far been given to establishing the total amounts of some estrogens in pre...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2012
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932323